Morbidity of Retropubic Radical Prostatectomy for Prostate Cancer in Renal Transplant Recipients: Multicenter Study from Renal Transplantation Committee of French Urological Association
Received 18 January 2008; accepted 15 March 2008. published online 24 April 2008.
Objectives
To evaluate the morbidity and surgical complications of retropubic radical prostatectomy (RRP) in renal transplant recipients (RTRs) and compare these results with the observed morbidity in a control group of nontransplanted patients.
Methods
We conducted a multicenter retrospective study and reviewed the charts and records of 20 RTRs who had undergone RRP for localized prostate cancer at four French renal transplant centers belonging to the Renal Transplantation Committee of the French Urological Association from April 1996 to April 2007. A total of 40 patients who had undergone RRP at the same centers, by the same surgeons, were analyzed as the case-control population.
Results
The mean operating time (163 ± 41 vs 160 ± 66 minutes), blood loss (516 ± 279 vs 566 ± 449 mL), transfusion rate (20% vs 22.5%), and hospital stay (11.9 ± 5.44 vs 9.45 ± 2.8 days) were similar in the RTR and case-control populations. No graft loss or graft injury was reported in the RTRs, except for two ureteral injuries that were immediately repaired during RRP. No decrease in the kidney graft function was observed after RRP. The rate of medical complication (deep venous thrombosis, pulmonary embolism, urinary tract infection) was similar in both groups, except for the rate of bacterial systemic infection, which was significantly greater in the RTRs than in the controls (15% vs 2.5%, P = .01).
Conclusions
In our study, RRP was a safe procedure to treat localized prostate cancer in RTRs. RRP resulted in the same morbidity in RTRs as in the case-control population.
aRenal Transplantation Committee, French Urological Association, Besançon, France
bDepartment of Urology and Renal Transplantation, University Hospital of Besançon, University of Franche-Comté, Besançon, France
cDepartment of Urology, University Hospital Salvator, Marseille, France
dDepartment of Urology, University Hospital SUD, Amiens, France
eDepartment of Urology, University Hospital of Grenoble, Grenoble, France
Reprint requests: François Kleinclauss, M.D., Ph.D., Service d'Urologie et Transplantation Rénale, Centre Hospitalier Universitaire de Besançon, 2 place Saint Jacques, Besançon F-25000 France
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