Urology
Volume 72, Issue 1 , Pages 29-32 , July 2008

Induction of Progressive Profound Hypocitraturia with Increasing Doses of Topiramate

Received 13 July 2007 ,Accepted 28 January 2008.

References 

  1. Brandes JL, Saper JR, Diamond M, et al. Topiramate for migraine prevention: a randomized controlled trial. JAMA. 2004;145:419–420
  2. Wasserstein AG, Rak I, Reife RA. Nephrolithiasis during treatment with topiramate. Epilepsia. 1995;36(suppl 3):153
  3. Wasserstein AG, Rak I, Reife RA. Investigation of the mechanistic basis for topiramate-associated nephrolithiasis: examination of urinary and serum constituents. Epilepsia. 1995;36(suppl 3):153
  4. Eggener S, Kim SC, User HM, et al. Urolithiasis associated with topiramate. Int Braz J Urol. 2004;30:29–31
  5. Kuo RL, Moran ME, Kim DH, et al. Topiramate-induced nephrolithiasis. J Endourol. 2002;16:229–231
  6. Lamb EJ, Stevens PE, Nashef L. Topiramate increases biochemical risk of nephrolithiasis. Ann Clin Biochem. 2004;41:166–169
  7. Takhar J, Manchanda R. Nephrolithiasis on topiramate therapy. Can J Psychiatry. 2000;45:491–493
  8. Dodgson SJ, Shank RP, Maryanoff BE. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000;41(suppl 1):35–39
  9. Welch BJ, Graybeal D, Orson WM, et al. Biochemical and stone-risk profiles with topiramate treatment. Am J Kidney Dis. 2006;48:555–563
  10. Easterling DE, Zakszewski T, Moyer MD, et al. Plasma pharmacokinetics of topiramate, a new anticonvulsant in humans. [abstract] Epilepsia. 1988;29:662
  11. Kossoff EH, Pyzik PL, Furth SL, et al. Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet. Epilepsia. 2002;43:1168–1171
  12. Brown D, Zhu XL, Sly WS. Localization of membrane-associated carbonic anhydrase type IV in kidney epithelial cells. Proc Natl Acad Sci U S A. 1990;87:7457–7461
  13. Hamm LL, Hering-Smith KS. Pathophysiology of hypocitraturic nephrolithiasis. Endocrinol Metab Clin N Am. 2002;31:885–893
  14. Aruga S, Wehrli S, Kaissling B, et al. Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int. 2000;58:206–215
  15. Jenkins AD, Dousa TP, Smith LH. Transport of citrate across renal brush border membrane: effects of dietary acid and alkali loading. Am J Physiol. 1985;249:F590–F595
  16. Winum JY, Temperini C, Cheikh KE, et al. Carbonic anhydrase inhibitors: clash with ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. J Med Chem. 2006;49:7024–7031

PII: S0090-4295(08)00122-2

doi: 10.1016/j.urology.2008.01.042

Urology
Volume 72, Issue 1 , Pages 29-32 , July 2008

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