Urology
Volume 71, Issue 5 , Pages 787-791 , May 2008

Body Mass Index, Prostate-Specific Antigen, and Digital Rectal Examination Findings Among Participants in a Prostate Cancer Screening Clinic

  • Marva M. Price

      Affiliations

    • Duke University Medical Center, Duke University School of Nursing, Durham, North Carolina
  • ,
  • Robert J. Hamilton

      Affiliations

    • Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Durham, North Carolina
    • Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
  • ,
  • Cary N. Robertson

      Affiliations

    • Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Durham, North Carolina
    • Surgery Section, Veterans Affairs Medical Center, Durham, North Carolina
  • ,
  • Maureen C. Butts

      Affiliations

    • Duke University Medical Center, Duke University School of Nursing, Durham, North Carolina
    • Duke University Medical Center, Department of Anesthesia, Durham, North Carolina
  • ,
  • Stephen J. Freedland

      Affiliations

    • Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Durham, North Carolina
    • Department of Pathology, Duke University School of Medicine, Durham, North Carolina
    • Duke University Medical Center, Department of Anesthesia, Durham, North Carolina
    • Corresponding Author InformationReprint requests: Dr. Stephen J. Freedland, Duke University School of Medicine, Box 2626 DUMC, Durham, NC 27710.

Received 21 August 2007 ,Accepted 5 November 2007.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66
  2. Ahn JO, Ku JH. Relationship between serum prostate-specific antigen levels and body mass index in healthy younger men. Urology. 2006;68:570–574
  3. Barqawi AB, Golden BK, O'Donnell C, et al. Observed effect of age and body mass index on total and complexed PSA: analysis from a national screening program. Urology. 2005;65:708–712
  4. Baillargeon J, Pollock BH, Kristal AR, et al. The association of body mass index and prostate-specific antigen in a population-based study. Cancer. 2005;103:1092–1095
  5. Fowke JH, Signorello LB, Chang SS, et al. Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men. Cancer. 2006;107:2361–2367
  6. Werny DM, Thompson T, Saraiya M, et al. Obesity is negatively associated with prostate-specific antigen in U.S. men, 2001–2004. Cancer Epidemiol Biomarkers Prev. 2007;16:70–76
  7. Schuurman AG, Goldbohm RA, Dorant E, et al. Anthropometry in relation to prostate cancer risk in the Netherlands Cohort Study. Am J Epidemiol. 2000;151:541–549
  8. Dal Maso L, Zucchetto A, La Vecchia C, et al. Prostate cancer and body size at different ages: an Italian multicentre case-control study. Br J Cancer. 2004;90:2176–2180
  9. Giovannucci E, Rimm EB, Stampfer MJ, et al. Height, body weight, and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 1997;6:557–563
  10. Robinson WR, Stevens J, Gammon MD, et al. Obesity before age 30 years and risk of advanced prostate cancer. Am J Epidemiol. 2005;161:1107–1114
  11. Kuczmarski RJ, Carroll MD, Flegal KM, et al. Varying body mass index cutoff points to describe overweight prevalence among U.S. adults: NHANES III (1988 to 1994). Obes Res. 1997;5:542–548
  12. Freedland SJ, Aronson WJ, Kane CJ, et al. Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group. J Clin Oncol. 2004;22:446–453
  13. Freedland SJ, Isaacs WB, Mangold LA, et al. Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years. Clin Cancer Res. 2005;11:2883–2888
  14. Strom SS, Kamat AM, Gruschkus SK, et al. Influence of obesity on biochemical and clinical failure after external-beam radiotherapy for localized prostate cancer. Cancer. 2006;107:631–639
  15. Strom SS, Wang X, Pettaway CA, et al. Obesity, weight gain, and risk of biochemical failure among prostate cancer patients following prostatectomy. Clin Cancer Res. 2005;11:6889–6894
  16. Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–1638
  17. Rodriguez C, Freedland SJ, Deka A, et al. Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev. 2007;16:63–69
  18. Rodriguez C, Patel AV, Calle EE, et al. Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States. Cancer Epidemiol Biomarkers Prev. 2001;10:345–353
  19. Wright ME, Chang SC, Schatzkin A, et al. Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer. 2007;109:675–684
  20. Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level < or = 4.0 ng per milliliter. N Engl J Med. 2004;350:2239–2246

 This study was supported by the Department of Veterans Affairs, the Department of Defense, Prostate Cancer Research Program (RJH and SJF), and the American Urological Association Foundation Astellas Rising Star in Urology Award (SJF). Views and opinions of, and endorsements by the author(s) do not reflect those of the US Army or the Department of Defense.

PII: S0090-4295(07)02407-7

doi: 10.1016/j.urology.2007.11.036

Urology
Volume 71, Issue 5 , Pages 787-791 , May 2008