Urology
Volume 72, Issue 1 , Pages 119-123, July 2008

Incisional Surgical Site Infection in Kidney Transplantation

  • Antonio Ramos

      Affiliations

    • Infectious Diseases Unit, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
    • Corresponding Author InformationReprint requests: Dr. Antonio Ramos, San Martín de Porres 4, 28035 Madrid, TF 34 913445000, 34 646 829 554, Spain.
    • ,
  • Angel Asensio

      Affiliations

    • Infectious Diseases Unit, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
    • ,
  • Elena Muñez

      Affiliations

    • Infectious Diseases Unit, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
    • ,
  • Julian Torre-Cisneros

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain
    • ,
  • Miguel Montejo

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain
    • ,
  • Jose Maria Aguado

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain
    • ,
  • Federico Cofán

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain
    • ,
  • Jordi Carratalá

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain
    • ,
  • Oscar Len

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain
    • ,
  • Jose Miguel Cisneros

      Affiliations

    • RESITRA (Network for the Study of Infections in Transplantation)-GESITRA (Infection in Transplant Study Group), REIPI (Spanish Network for the Research in Infectious Diseases), Spain

Received 22 July 2007; accepted 8 November 2007. published online 15 February 2008.

Objectives

Incisional surgical site infections are common bacterial infections in kidney transplantation. The purpose of this study was to determine the incidence, timing, etiology, and risk factors for incisional surgical site infections.

Methods

We performed a prospective study that included a population of 1400 consecutive patients (58.4% males) who underwent kidney transplantation in Spanish hospitals pertaining to the RESITRA research network.

Results

A total of 55 patients developed 63 episodes of incisional surgical site infections. Median time from transplant to incisional surgical site infections was 20 days (range, 2 to 76 days). All infected patients recovered from incisional surgical site infections. The most frequently isolated pathogens were Escherichia coli (31.7%), Pseudomonas aeruginosa (13.3%), Enterococcus faecalis (11.6%), Enterobacter spp. (10%), and coagulase-negative staphylococci (8.3%). Diabetic patients had an increased risk of incisional surgical site infections (7.5%, P = 0.013). We used several different regimens of antimicrobial prophylaxis. None were found to be associated with an increased risk of incisional surgical site infections. The use of sirolimus was associated with an increased risk of incisional surgical site infections (7.4%, P = 0.018).

Conclusions

Diabetic patients, and those who received sirolimus-based immunosuppressive regimens, showed an increased risk of developing incisional surgical site infections after kidney transplantation.

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 RESITRA (Network for the Study of Infections in Transplantation) is a research network consisting of several Spanish public hospitals, with funding granted by the Spanish National Health Service.

PII: S0090-4295(07)02400-4

doi:10.1016/j.urology.2007.11.030

Urology
Volume 72, Issue 1 , Pages 119-123, July 2008

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