Relationship of Prostate-Specific Antigen and Prostate Volume in Korean Men with Biopsy-Proven Benign Prostatic Hyperplasia

Lee, Sang Eun; Chung, Jae Seung; Han, Byung Kyu; Moon, Ki Hyuk; Hwang, Sung Il; Lee, Hak Jong; Choe, Gheeyoung; Hong, Sung Kyu

doi:10.1016/j.urology.2007.10.019

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Volume 71, Issue 3 , Pages 395-398, March 2008

Relationship of Prostate-Specific Antigen and Prostate Volume in Korean Men with Biopsy-Proven Benign Prostatic Hyperplasia

Sang Eun Lee
- Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
Jae Seung Chung
- Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
Byung Kyu Han
- Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
Ki Hyuk Moon
- Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
Sung Il Hwang
- Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea
Hak Jong Lee
- Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea
Gheeyoung Choe
- Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea
Sung Kyu Hong
- Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
- Reprint requests: Sung Kyu Hong, M.D., Ph.D., Department of Urology, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam, Kyunggi-do, Korea 463-707.

Received 10 June 2007; accepted 19 October 2007.

Objectives

To investigate the relationship between prostate-specific antigen (PSA) and prostate volume in a histologically defined subset of Korean men confirmed to have benign prostatic hyperplasia (BPH) only from multicore biopsy of prostate.

Methods

A total of 707 Korean men with a PSA level of 10 ng/mL or lower who were shown to have stromoglandular hyperplasia only from transrectal ultrasound (TRUS)-guided multicore biopsy of prostate were included in the study. We analyzed PSA and total prostate volume (TV) measured through TRUS by stratified age cohorts. We used Pearson correlation coefficient (r) and linear regression model to describe the relationship between variables.

Results

Serum PSA level significantly correlated with TV in all stratified age cohorts, with r ranging from 0.29 to 0.47 (all P <0.001). Meanwhile, the degree of correlation appeared to increase with age. The slope of linear regression showing an association of PSA and TV was 3.68. The PSA increase per unit prostate volume decreased with the advancing cohort of age when we excluded subjects 70 years or older.

Conclusions

Although PSA was significantly correlated with TV, the exact nature of the relationship between PSA and TV in Korean men with biopsy-proven BPH may be different from that in other races. Further basic research on the pathophysiology of BPH is needed to explain such a racial difference.