Urology
Volume 71, Issue 1 , Pages 57-61 , January 2008

Time to Initiation of Pentosan Polysulfate Sodium Treatment After Interstitial Cystitis Diagnosis: Effect on Symptom Improvement

Presented at the meeting of the American Urologynecologic Society, Palm Springs, Calif, October 19-21, 2006.

  • J. Curtis Nickel

      Affiliations

    • Queen’s University, Kingston, Ontario, Canada
    • Dr. Nickel is a consultant and has served on the speakers’ bureau for Ortho-McNeil Pharmaceutical, Inc.
    • Corresponding Author InformationReprint requests: J. Curtis Nickel, MD, FRCS(C), Queens University Department of Urology, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada K7L2V7.
    • ,
  • David M. Kaufman

      Affiliations

    • Central Park Urology, New York, New York
    • Dr. Kaufman has served on the speakers’ bureau for Ortho-McNeil Pharmaceutical, Inc. and Bayer Pharmaceuticals.
    • ,
  • Huabin F. Zhang

      Affiliations

    • Ortho Women’s Health & Urology, a Division of Ortho-McNeil Pharmaceutical, Inc, Raritan, New Jersey
    • ,
  • George J. Wan

      Affiliations

    • Ortho Women’s Health & Urology, a Division of Ortho-McNeil Pharmaceutical, Inc, Raritan, New Jersey
    • ,
  • Peter K. Sand

      Affiliations

    • Evanston Continence Center, Northwestern University, Evanston, Illinois
    • Dr. Sand has received research support and has served as a consultant and a member of the speakers’ bureau for Ortho-McNeil Pharmaceutical, Inc.

Received 26 April 2007 ,Accepted 13 September 2007.

References 

  1. Hanno PM. Interstitial cystitis and related disorders. In:  Walsh PC,  Retik AB,  Vaughan ED,  Wein AJ editor. 8th ed.. Campbell’s Urology. vol 1:Philadelphia: WB Saunders; 2002;p. 631–670
  2. Michael YL, Kawachi I, Stampfer MJ, et al. Quality of life among women with interstitial cystitis. J Urol. 2000;164:423–427
  3. Held PJ, Hanno PM, Wein AJ, et al. Epidemiology of interstitial cystitis: 2. In:  Hanno PM,  Staskin DR,  Krane RJ,  Wein AJ editor. Interstitial cystitis. London: Springer-Verlag; 1990;p. 29–48
  4. Driscoll A, Teichman JMH. How do patients with interstitial cystitis present?. J Urol. 2001;166:2118–2120
  5. Porru D, Politanò R, Gerardini M, et al. Different clinical presentation of interstitial cystitis syndrome. Int Urogynecol J Pelvic Floor Dysfunct. 2004;15:198–202
  6. Rovner E, Propert KJ, Brensinger C, et al. Treatments used in women with interstitial cystitis: the Interstitial Cystitis Data Base (ICDB) study experience. Urology. 2000;56:940–945
  7. Wu EQ, Birnbaum H, Mareva M, et al. Interstitial cystitis: cost, treatment and co-morbidities in an employed population. Pharmacoeconomics. 2006;24:55–65
  8. ELMIRON (pentosan polysulfate sodium). [package insert] Raritan, NJ: Ortho-McNeil Pharmaceutical, Inc; 2007;
  9. Nickel JC, Barkin J, Forrest J, et al. Elmiron Study Group Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis. Urology. 2005;65:654–658
  10. O’Leary MP, Sant GR, Fowler FJ, et al. The interstitial cystitis symptom index and problem index. Urology. 1997;49(suppl 5A):58–63
  11. Forrest JB, Sebastyanski P, and O’Brien-Westbrook M: Observations on the clinical factors affecting the treatment outcomes of interstitial cystitis. Poster presented at: International Pelvic Pain Society (IPPS) Annual Meeting; August 5–7, 2004; Chicago, Ill.
  12. Parsons CL, Benson G, Childs SJ, et al. A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol. 1993;150:845–848
  13. Mulholland SG, Hanno P, Parsons CL, et al. Pentosan polysulfate sodium for therapy of interstitial cystitis: a double-blind placebo-controlled clinical study. Urology. 1990;35:552–558
  14. Parsons CL, Mulholland SG. Successful therapy of interstitial cystitis with pentosanpolysulfate. J Urol. 1987;138:513–516
  15. Holm-Bentzen M, Jacobsen F, Nerstrøm B, et al. A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease. J Urol. 1987;138:503–507
  16. Sant GR, Propert KJ, Hanno PM, et al. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. J Urol. 2003;170:810–815
  17. Lubeck DP, Whitmore K, Sant GR, et al. Psychometric validation of the O’Leary-Sant Interstitial Cystitis Symptom Index in a clinical trial of pentosan polysulfate sodium. Urology. 2001;57(suppl 6A):62–66
  18. Efficacy of amitriptyline for painful bladder syndrome (PBS). http://clinicaltrialsgov/ct/show/NCT00124306?order=2Accessed December 1, 2006

 Support was provided by Ortho Women’s Health & Urology, a Division of Ortho-McNeil Pharmaceutical, Inc.

PII: S0090-4295(07)02145-0

doi: 10.1016/j.urology.2007.09.013

Urology
Volume 71, Issue 1 , Pages 57-61 , January 2008

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