Urology
Volume 69, Issue 3 , Pages 532-535 , March 2007

PCA3 Molecular Urine Assay for Prostate Cancer in Men Undergoing Repeat Biopsy

This work was presented in part at the Annual Meeting of the American Urological Association, Atlanta, Georgia, May 2006.

  • Leonard S. Marks

      Affiliations

    • Urological Sciences Research Foundation, University of California, Los Angeles, California
    • Department of Urology, University of California, David Geffen School of Medicine, Los Angeles, California
    • Corresponding Author InformationReprint requests: Leonard S. Marks, M.D., Urological Sciences Research Foundation, 3831 Hughes Avenue, Culver City, CA 90232.
    • L. S. Marks has served as a speaker, paid consultant, and study investigator for Gen-Probe and Beckman-Coulter, Inc.
    • ,
  • Yves Fradet

      Affiliations

    • Universite Laval, Quebec City, Quebec, Canada
    • Y. Fradet has served as a speaker, paid consultant, and study investigator for Gen-Probe and DiagnoCure.
    • ,
  • Ina Lim Deras

      Affiliations

    • Gen-Probe Incorporated, San Diego, California
    • ,
  • Amy Blase

      Affiliations

    • Gen-Probe Incorporated, San Diego, California
    • ,
  • Jeannette Mathis

      Affiliations

    • Gen-Probe Incorporated, San Diego, California
    • ,
  • Sheila M.J. Aubin

      Affiliations

    • Gen-Probe Incorporated, San Diego, California
    • ,
  • Anthony T. Cancio

      Affiliations

    • Urological Sciences Research Foundation, University of California, Los Angeles, California
    • ,
  • Marie Desaulniers

      Affiliations

    • Universite Laval, Quebec City, Quebec, Canada
    • ,
  • William J. Ellis

      Affiliations

    • Department of Urology, University of Washington School of Medicine, Seattle, Washington
    • W. J. Ellis has served as a speaker, paid consultant, and study investigator for Gen-Probe.
    • ,
  • Harry Rittenhouse

      Affiliations

    • Gen-Probe Incorporated, San Diego, California
    • ,
  • Jack Groskopf

      Affiliations

    • Gen-Probe Incorporated, San Diego, California

Received 8 July 2006 ,Accepted 12 December 2006.

References 

  1. Freedland SJ, Partin AW. Prostate-specific antigen: update 2006. Urology. 2006;67:458–460
  2. Thompson IM, Ankerst DP, Chi C, et al. Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower. JAMA. 2005;294:66–70
  3. Stamey TA, Caldwell M, McNeal JE, et al. The prostate specific antigen era in the United States is over for prostate cancer: what happened in the last 20 years?. J Urol. 2004;172:1297–1301
  4. Bussemakers MJ, van Bokhoven A, Verhaegh GW, et al. DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res. 1999;59:5975–5979
  5. Hessels D, Klein Gunnewiek JM, et al. DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. Eur Urol. 2003;44:8–16
  6. de Kok JB, Verhaegh GW, Roelofs RW, et al. DD3(PCA3), a very sensitive and specific marker to detect prostate tumors. Cancer Res. 2002;62:2695–2698
  7. Fradet Y, Saad F, Aprikian A, et al. uPM3, a new molecular urine test for the detection of prostate cancer. Urology. 2004;64:311–316
  8. Tinzl M, Marberger M, Horvath S, et al. DD3PCA3 RNA analysis in urine—a new perspective for detecting prostate cancer. Eur Urol. 2004;46:182–187
  9. Groskopf J, Aubin SMJ, Deras IL, et al. APTIMA PCA3 molecular urine test: development of a method to aid in the diagnosis of prostate cancer. Clin Chem. 2006;52:1089–1095
  10. Marks LS, Epstein JI, Partin AW. The role of prostate needle biopsy in evaluation of chemopreventive agents. Urology. 2001;57(suppl 4a):191–193
  11. Giachetti C, Linnen JM, Kolk DP, et al. Highly sensitive multiplex assay for detection of human immunodeficiency virus type 1 and hepatitis C virus RNA. J Clin Microbiol. 2002;40:2408–2419
  12. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
  13. Thompson IM, Carroll P, Coley C, et al. Prostate-specific antigen (PSA) best practice policy. Oncology. 2000;14:267–286
  14. Vollmer RT. Predictive probability of serum prostate-specific antigen for prostate cancer: an approach using Bayes rule. Am J Clin Pathol. 2006;125:336–342
  15. Roehl KA, Antenor JA, Catalona WJ. Serial biopsy results in prostate cancer screening study. J Urol. 2002;167:2435–2439

PII: S0090-4295(06)02638-0

doi: 10.1016/j.urology.2006.12.014

Urology
Volume 69, Issue 3 , Pages 532-535 , March 2007

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