Urology
Volume 69, Issue 3 , Pages 505-509 , March 2007

Activated STAT3 as a Correlate of Distant Metastasis in Prostate Cancer: A Secondary Analysis of Radiation Therapy Oncology Group 86-10

  • Javier F. Torres-Roca

      Affiliations

    • Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    • Corresponding Author InformationReprint requests: Javier F. Torres-Roca, M.D., Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612.
    • ,
  • Michelle DeSilvio

      Affiliations

    • Radiation Therapy Oncology Group, American College of Radiology, Philadelphia, Pennsylvania
    • ,
  • Linda B. Mora

      Affiliations

    • Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    • ,
  • Li Yan Khor

      Affiliations

    • Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    • ,
  • Elizabeth Hammond

      Affiliations

    • Department of Pathology, Latter-Day Saints Hospital, Intermountain Health Care, Salt Lake City, Utah
    • ,
  • Nazeel Ahmad

      Affiliations

    • Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    • ,
  • Richard Jove

      Affiliations

    • Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    • ,
  • Jeffrey Forman

      Affiliations

    • Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, Michigan
    • ,
  • R. Jeffrey Lee

      Affiliations

    • Department of Radiation Oncology, LDH Hospital, Salt Lake City, Utah
    • ,
  • Howard Sandler

      Affiliations

    • Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan
    • ,
  • Alan Pollack

      Affiliations

    • Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania

Received 13 June 2006 ,Accepted 16 November 2006.

References 

  1. Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res. 2002;8:945–954
  2. Alvarez J, Frank D. Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. Cancer Biol Ther. 2004;3:1045–1050
  3. Clevenger CV. Roles and regulation of STAT family transcription factors in human breast cancer. Am J Pathol. 2004;165:1449–1460
  4. Mora LB, Buettner R, Seigne J, et al. Constitutive activation of STAT3 in human prostate tumors and cell lines: direct inhibition of STAT3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 2002;62:6659–6666
  5. Dhir R, Ni Z, Lou W, et al. STAT3 activation in prostatic carcinomas. Prostate. 2002;51:241–246
  6. Horinaga M, Okita H, Nakashima J, et al. Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer. Urology. 2005;66:671–675
  7. In: CPA, a Novel STAT3 Inhibitor Radiosensitizes Prostate Cancer Cells. vol 63:Denver, Colorado: ASTRO; 2005;S483–S83
  8. Chakravarti A, Heydon K, Wu CL, et al. Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: an analysis from the Radiation Therapy Oncology Group protocol 86-10. J Clin Oncol. 2003;21:3328–3334
  9. Li R, Heydon K, Hammond ME, et al. Ki-67 staining index predicts distant metastasis and survival in locally advanced prostate cancer treated with radiotherapy: an analysis of patients in Radiation Therapy Oncology Group protocol 86-10. Clin Cancer Res. 2004;10:4118–4124
  10. Pollack A, Grignon DJ, Heydon KH, et al. Prostate cancer DNA ploidy and response to salvage hormone therapy after radiotherapy with or without short-term total androgen blockade: an analysis of RTOG 8610. J Clin Oncol. 2003;21:1238–1248
  11. Pollack A, DeSilvio M, Khor LY, et al. Ki-67 staining is a strong predictor of distant metastasis and mortality for men with prostate cancer treated with radiotherapy plus androgen deprivation: Radiation Therapy Oncology Group trial 92-02. J Clin Oncol. 2004;22:2133–2140
  12. Pilepich MV, Winter K, John MJ, et al. Phase III Radiation Therapy Oncology Group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2001;50:1243–1252
  13. Cox D. Regression models and life-tables. J R Stat Soc. 1972;34:187–202
  14. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  15. Kalbfleish J, Prentice R. In: The Statistical Analysis of Failure Time Data. New York: John Wiley and Sons; 1980;p. 167–169
  16. Dolled-Filhart M, Camp RL, Kowalski DP, et al. Tissue microarray analysis of signal transducers and activators of transcription 3 (STAT3) and Phospho-STAT3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. Clin Cancer Res. 2003;9:594–600
  17. Kusaba T, Nakayama T, Yamazumi K, et al. Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma: correlation with clinicopathological factors. J Clin Pathol. 2005;58:833–838
  18. Xie T-X, Wei D, Liu M, et al. STAT3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 2004;23:3550–3560
  19. Ling X, Arlinghaus RB. Knockdown of STAT3 Expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 2005;65:2532–2536

 This study was supported by Radiation Therapy Oncology Group Pilot Seed grant RTOG-TRP-003, National Cancer Institute grant K08 CA 108926-01 to J. Torres-Roca, and a Pennsylvania Department of Health Grant.

PII: S0090-4295(06)02521-0

doi: 10.1016/j.urology.2006.11.006

Urology
Volume 69, Issue 3 , Pages 505-509 , March 2007

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