Urology
Volume 68, Issue 3, Supplement , Pages 26-37 , September 2006

Erectile function and assessments of erection hardness correlate positively with measures of emotional well-being, sexual satisfaction, and treatment satisfaction in men with erectile dysfunction treated with sildenafil citrate (Viagra®)

  • Francesco Montorsi

      Affiliations

    • Department of Urology, Università Vita e Salute San Raffaele, Milan, Italy
    • Francesco Montorsi and Harin Padma-Nathan are paid consultants to, and study investigators partially funded by, Pfizer Inc.
    • Corresponding Author InformationReprint requests: Francesco Montorsi, MD, Department of Urology, Via Olgettina 60, Milan 20132, Italy.
  • ,
  • Harin Padma-Nathan

      Affiliations

    • Keck School of Medicine at the University of Southern California, Los Angeles, California, USA
    • Francesco Montorsi and Harin Padma-Nathan are paid consultants to, and study investigators partially funded by, Pfizer Inc.
  • ,
  • Sidney Glina

      Affiliations

    • Instituto H. Ellis, São Paulo, Brazil.
    • Sidney Glina is a member of the medical advisory board for, and paid consultant to, Pfizer Inc.

References 

  1. Feldman HA , Goldstein I , Hatzichristou DG , et al.   Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study . J Urol . 1994;151:54–61
  2. Althof SE . Quality of life and erectile dysfunction . Urology . 2002;59:803–810
  3. Ehrensaft MK , Condra M , Morales A , et al.   Communication patterns in patients with erectile dysfunction and their partners . Int J Impot Res . 1994;6:25–32
  4. Rust J , Golombok S , Collier J . Marital problems and sexual dysfunction: how are they related? . Br J Psychiatry . 1988;152:629–631
  5. Cappelleri JC , Althof SE , Siegel RL , et al.   Development and validation of the Self-Esteem And Relationship (SEAR) questionnaire in erectile dysfunction . Int J Impot Res . 2004;16:30–38
  6. Althof SE , Cappelleri JC , Shpilsky A , et al.   Treatment responsiveness of the Self-Esteem And Relationship questionnaire in erectile dysfunction . Urology . 2003;61:888–892
  7. Data on file . New York: Pfizer Inc; 2005;
  8. Althof SE, O’Leary MP, Cappelleri JC, et al: Self esteem, confidence, and relationships in men with erectile dysfunction treated with sildenafil citrate: pooled analysis of two double-blind placebo-controlled trials. J Gen Int Med, in press
  9. Stecher VJ . Near-normalization of erectile function and improvement of psychosocial quality-of-life in men with erectile dysfunction treated with Viagra® (sildenafil citrate) . J Sex Med . 2005;83(suppl 1):P-158
  10. Boolell M , Allen MJ , Ballard SA , et al.   Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction . Int J Impot Res . 1996;8:47–52
  11. Boolell M , Gepi-Attee S , Gingell JC , et al.   Sildenafil, a novel effective oral therapy for male erectile dysfunction . Br J Urol . 1996;78:257–261
  12. Eardley I , Ellis P , Boolell M , et al.   Onset and duration of action of sildenafil citrate for the treatment of erectile dysfunction . Br J Clin Pharmacol . 2002;53:61S–65S
  13. Gingell C , Sultana S , Hodgson G , et al.   Duration of action of sildenafil citrate in men with erectile dysfunction . J Sex Med . 2004;1:179–184
  14. Mulhall JP , Levine LA , Jünemann K-P . Erection hardness: a unifying factor for defining response in the treatment of erectile dysfunction . Urology . 2006;68:17–25
  15. Williams B . Patient satisfaction: a valid concept? . Soc Sci Med . 1994;38:509–516
  16. Boulton AJ , Selam JL , Sweeney M , et al.   Sildenafil citrate for the treatment of erectile dysfunction in men with type II diabetes mellitus . Diabetologia . 2001;44:1296–1301
  17. Cappelleri JC , Siegel RL , Osterloh IH , et al.   Relationship between patient self-assessment of erectile function and the erectile function domain of the international index of erectile function . Urology . 2000;56:477–481
  18. DeBusk RF , Pepine CJ , Glasser DB , et al.   Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery disease . Am J Cardiol . 2004;93:147–153
  19. Dinsmore WW , Hodges M , Hargreaves C , et al.   Sildenafil citrate (Viagra) in erectile dysfunction: near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects . Urology . 1999;53:800–805
  20. Glina S , Bertero E , Claro J , et al.   Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction in Brazilian and Mexican men . Int J Impot Res . 2002;14(suppl 2):S27–S32
  21. Glina S , Bertero E , Claro J , et al.   Efficacy and safety of sildenafil citrate for the treatment of erectile dysfunction in Latin America . Braz J Urol . 2001;27:148–154
  22. Goldstein I , Lue TF , Padma-Nathan H , et al.   Oral sildenafil in the treatment of erectile dysfunction . N Engl J Med . 1998;338:1397–1404
  23. Katz SD , Parker JD , Glasser DB , et al.   Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure . Am J Cardiol . 2005;95:36–42
  24. Kongkanand A , Ratana-Olarn K , Ruangdilokrat S , et al.   The efficacy and safety of oral sildenafil in Thai men with erectile dysfunction: a randomized, double-blind, placebo controlled, flexible-dose study . J Med Assoc Thai . 2003;86:195–205
  25. Levinson IP , Khalaf IM , Shaeer KZ , et al.   Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa . Int J Impot Res . 2003;15(suppl 1):S25–S29
  26. Lewis R , Bennett CJ , Borkon WD , et al.   Patient and partner satisfaction with Viagra (sildenafil citrate) treatment as determined by the erectile dysfunction inventory of treatment satisfaction questionnaire . Urology . 2001;57:960–965
  27. Meuleman E , Cuzin B , Opsomer RJ , et al.   A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction . BJU Int . 2001;87:75–81
  28. Olsson AM , Persson CA . Efficacy and safety of sildenafil citrate for the treatment of erectile dysfunction in men with cardiovascular disease . Int J Clin Pract . 2001;55:171–176
  29. Padma-Nathan H , Steers WD , Wicker PA , et al.   Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: a double-blind, placebo-controlled study of 329 patients . Int J Clin Pract . 1998;52:375–380
  30. Pickering TG , Shepherd AM , Puddey IB , et al.   Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized controlled trial . Am J Hypertens . 2004;17:1135–1142
  31. Rendell MS , Rajfer J , Wicker PA , et al.   Sildenafil for treatment of erectile dysfunction in men with diabetes . JAMA . 1999;281:421–426
  32. Seidman SN , Roose SP , Menza MA , et al.   Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate . Am J Psychiatry . 2001;158:1623–1630
  33. Stuckey BG , Jadzinsky MN , Murphy LJ , et al.   Sildenafil citrate for treatment of erectile dysfunction in men with type 1 diabetes: results of a randomized controlled trial . Diabetes Care . 2003;26:279–284
  34. Tan HM , Moh CL , Mendoza JB , et al.  The Assess-1 Study Group   Asian sildenafil efficacy and safety study (ASSESS-1): a double-blind, placebo-controlled, flexible-dose study of oral sildenafil in Malaysian, Singaporean, and Filipino men with erectile dysfunction . Urology . 2000;56:635–640
  35. Tignol J , Furlan PM , Gomez-Beneyto M , et al.   Efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in remission from depression . Int Clin Psychopharmacol . 2004;19:191–199
  36. Young JM , Bennett C , Gilhooly P , et al.   Efficacy and safety of sildenafil citrate (Viagra®) in black and Hispanic American men . Urology . 2002;60:39–48
  37. Stecher V , Wang H . Treatment satisfaction with Viagra® (sildenafil citrate) in men with erectile dysfunction: combined analysis of 6 trials . J Sex Med . 2005;62(suppl 1):P-085
  38. NIH Consensus Development Panel on Impotence . NIH Consensus Conference: impotence . JAMA . 1993;270:83–90
  39. Rosen RC , Cappelleri JC , Smith MD , et al.   Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction . Int J Impot Res . 1999;11:319–326
  40. Padma-Nathan H . Oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction: assessment of erections hard enough for sexual intercourse . Int J Clin Pract . 1999;102(suppl):13–15
  41. Althof SE , Corty EW , Levine SB , et al.   EDITS: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction . Urology . 1999;53:793–799
  42. Rosen RC , Riley A , Wagner G , et al.   The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction . Urology . 1997;49:822–830
  43. Cappelleri JC , Rosen RC , Smith MD , et al.   Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function . Urology . 1999;54:346–351
  44. Rosen RC , Althof SE , Giuliano F . Research instruments for the diagnosis and treatment of patients with erectile dysfunction . Urology . 2006;68:6–16
  45. Eardley I , Wright P , MacDonagh R , et al.   An open-label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil citrate and apomorphine hydrochloride in men with erectile dysfunction . BJU Int . 2004;93:1271–1275

PII: S0090-4295(06)00892-2

doi: 10.1016/j.urology.2006.06.027

Urology
Volume 68, Issue 3, Supplement , Pages 26-37 , September 2006