« Previous
Urology
Volume 68, Issue 3,
Supplement
, Pages 47-60
, September 2006
Cardiovascular safety of sildenafil citrate (Viagra®): An updated perspective
References
-
Data on file
. New York, NY: Pfizer Inc; 2005;
- A 4-year update on the safety of sildenafil citrate (Viagra®) . Urology . 2002;60(suppl 2B):67–90
- American College of Cardiology/American Heart Association Writing Group: ACC/AHA expert consensus document: use of sildenafil (Viagra) in patients with cardiovascular disease . J Am Coll Cardiol . 1999;33:273–282
- Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton Consensus Panel . Am J Cardiol . 2000;86:175–181
- A systematic approach to erectile dysfunction in the cardiovascular patient: a consensus statement . Int J Clin Pract . 1999;53:445–451
- A systematic approach to erectile dysfunction in the cardiovascular patient: a Consensus Statement—update 2002 . Int J Clin Pract . 2002;56:663–671
-
Sexual dysfunction and cardiac risk: the 2nd Princeton Consensus Conference
.
Am J Cardiology
. 2005;96:313–321
-
.
Viagra (Sildenafil Citrate): The Remarkable Story of the Discovery and Launch
. New York: Medical Information Press; 2001;
-
.
Sildenafil and the NO/cGMP signaling pathway
.
In:
Kloner R
editors.
Heart Disease and Erectile Dysfunction
. Totowa, NJ: Humana Press; 2004;p. 89–116
- Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes . J Urol . 1998;159:2164–2171
- Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro . Br J Urol . 1997;79:958–963
- Structure and function of cGMP-dependent protein kinases . Rev Physiol Biochem Pharmacol . 1999;135:105–149
- . Store-operated calcium entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism . J Biol Chem . 2000;275:6758–6763
- Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase I alpha . Science . 1999;286:1583–1587
- . Fundamentals of endothelial function for the clinical cardiologist . Circulation . 2002;105:546–549
- Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study . J Urol . 1994;151:54–61
- The effect of sildenafil on nitric oxide–mediated vasodilation in healthy men . Clin Pharmacol Ther . 2001;70:270–279
- Effects of sildenafil citrate on human hemodynamics . Am J Cardiol . 1999;83:13C–20C
- Overall cardiovascular profile of sildenafil citrate . Am J Cardiol . 1999;83:35C–44C
- . Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication . J Hypertens . 2000;18:1865–1869
- Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized controlled trial . Am J Hypertens . 2004;17:1135–1142
- Sildenafil citrate and blood-pressure–lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist . Am J Cardiol . 1999;83:21C–28C
- Effects of sildenafil citrate (Viagra) on blood pressure in normotensive and hypertensive men . Urology . 2002;59:747–752
- Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial . JAMA . 2002;287:719–725
- Hemodynamic effects of sildenafil in patients with stable ischemic heart disease . Int J Cardiol . 2003;90:153–157
- Hemodynamic effects of sildenafil in men with severe coronary artery disease . N Engl J Med . 2000;342:1622–1626
- Effects of sildenafil citrate (Viagra®) on hemodynamic parameters during exercise testing and occurrence of ventricular arrhythmias in patients with erectile dysfunction and cardiovascular disease . Eur Urol . 2003;43:544–551
- Sildenafil citrate does not affect cardiac contractility in human or dog heart . Curr Med Res Opin . 2003;19:747–752
- Hemodynamic effects of sildenafil citrate and isosorbide mononitrate in men with coronary artery disease and erectile dysfunction . J Sex Med . 2005;2:407–414
- The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia . J Am Coll Cardiol . 2002;40:1232–1240
- on behalf of the CAESAR I (Clinical American and European Studies of Angina and Revascularization) investigators: Sildenafil citrate does not reduce exercise tolerance in men with erectile dysfunction and chronic stable angina . Eur Heart J . 2003;24:2206–2212
- Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers . Ital Heart J . 2001;2:841–844
- Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil . Eur J Pharmacol . 2004;502:163–167
- Sildenafil citrate does not affect QT intervals and QT dispersion: an important observation for drug safety . Ann Noninvasive Electrocardiol . 2003;8:14–17
- Sildenafil citrate does not alter ventricular repolarization properties: novel evidence from dynamic QT analysis . Ann Noninvasive Electrocardiol . 2004;9:228–233
- Evaluation of vardenafil and sildenafil on cardiac repolarization . Am J Cardiol . 2004;93:1378–1383
- Clinical safety of oral sildenafil citrate (VIAGRA) in the treatment of erectile dysfunction . Int J Impot Res . 1998;10:69–74
- . Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease . Am J Cardiol . 1999;83:29C–34C
- Sildenafil Study Group: Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy . Am J Hypertens . 2001;14:70–73
- . Clinical trials of sildenafil citrate (Viagra) demonstrate no increase in risk of myocardial infarction and cardiovascular death compared with placebo . Int J Clin Pract . 2003;57:597–600
- . Evaluation of acute risk for myocardial infarction in men treated with sildenafil citrate . Am J Cardiol . 2005;96:443–446
- . Evaluation of the safety of sildenafil for male erectile dysfunction: experience gained in general practice use in England in 1999 . BJU Int . 2004;93:796–801
- Cardiovascular events in users of sildenafil: results from first phase of prescription event monitoring in England . BMJ . 2001;322:651–652
-
Cardiovascular safety of Viagra® (sildenafil citrate): results of the international men’s health study
.
[Abstract]
Eur Urol
. 2005;4(suppl 3):137
- Treatment program for erectile dysfunction in patients with cardiovascular diseases . Am J Cardiol . 2004;93:689–693
- Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery disease . Am J Cardiol . 2004;93:147–153
- Erectile dysfunction in essential arterial hypertension and effects of sildenafil: results of a Spanish national study . Am J Hypertens . 2004;17:139–145
- Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction . Int J Impot Res . 1999;11:319–326
- . Efficacy and safety of sildenafil citrate for the treatment of erectile dysfunction in men with cardiovascular disease . Int J Clin Pract . 2001;55:171–176
-
Viagra® (sildenafil citrate) [full prescribing information]
. New York, NY: Pfizer Inc; 2005;
- . Sexual activity as a trigger for cardiovascular events: what is the risk? . Am J Cardiol . 1999;84:2N–5N
- Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina . J Am Coll Cardiol . 2000;36:25–31
PII: S0090-4295(06)00891-0
doi: 10.1016/j.urology.2006.05.047
© 2006 Elsevier Inc. All rights reserved.
« Previous
Urology
Volume 68, Issue 3,
Supplement
, Pages 47-60
, September 2006
