Urology
Volume 68, Issue 3 , Pages 578-582 , September 2006

Inactivation of myopodin expression associated with prostate cancer relapse

  • Yan Ping Yu

      Affiliations

    • Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    • ,
  • George C. Tseng

      Affiliations

    • Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Jian-Hua Luo

      Affiliations

    • Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    • Corresponding Author InformationReprint requests: Jian-Hua Luo, M.D., Ph.D., Department of Pathology, University of Pittsburgh, Scaife Hall S-760, 3550 Terrace Street, Pittsburgh, PA 15261.

Received 15 December 2005 ,Accepted 13 March 2006.

References 

  1. Isaacs JT . Molecular markers for prostate cancer metastasis: developing diagnostic methods for predicting the aggressiveness of prostate cancer . Am J Pathol . 1997;150:1511–1521
  2. Jemal A , Murray T , Ward E , et al.   Cancer statistics, 2005 . CA Cancer J Clin . 2005;55:10–30
  3. Lin F , Yu YP , Woods J , et al.   Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers . Am J Pathol . 2001;159:1603–1612
  4. Mundel P , Reiser J , Zuniga Mejia Borja A , et al.   Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines . Exp Cell Res . 1997;236:248–258
  5. Nagata M , Nakayama K , Terada Y , et al.   Cell cycle regulation and differentiation in the human podocyte lineage . Am J Pathol . 1998;153:1511–1520
  6. Sanchez-Carbayo M , Schwarz K , Charytonowicz E , et al.   Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome . Oncogene . 2003;22:5298–5305
  7. Jing L , Liu L , Yu YP , et al.   Expression of myopodin induces suppression of tumor growth and metastasis . Am J Pathol . 2004;164:1799–1806

 This work was supported by grants from the National Cancer Institute (1UO1CA88110-01 and R01 CA098249) and John Rangos Foundation for Enhancement of Research in Pathology.

PII: S0090-4295(06)00371-2

doi: 10.1016/j.urology.2006.03.027

Urology
Volume 68, Issue 3 , Pages 578-582 , September 2006

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