Solitary ureteral metastases of renal cell carcinoma

Zorn, Kevin C.; Orvieto, Marcelo A.; Mikhail, Albert A.; Lotan, Tamara; Gerber, Glenn S.; Shalhav, Arieh L.; Steinberg, Gary D.

doi:10.1016/j.urology.2006.03.012

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Volume 68, Issue 2 , Pages 428.e5-428.e7, August 2006

Solitary ureteral metastases of renal cell carcinoma

Kevin C. Zorn
- Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
- Address for correspondence: Kevin C. Zorn, M.D., Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, 5841 South Maryland Avenue, MC6038 J-653, Chicago, IL 60637.
Marcelo A. Orvieto
- Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
Albert A. Mikhail
- Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
Tamara Lotan
- Section of Pathology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois
Glenn S. Gerber
- Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
Arieh L. Shalhav
- Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
Gary D. Steinberg
- Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA

Received 9 December 2005; accepted 8 March 2006.

Abstract

Metachronous presentation of metastatic renal cell carcinoma (RCC) to the ureter is extremely rare. We report a solitary metachronous metastatic RCC in the contralateral ureter 14 months after right radical nephrectomy for Fuhrman grade 2 pT3a clear cell disease after the patient re-presented with gross hematuria. The proximal left ureteral lesion was excised followed by ileal-ureteral interposition. Pathologic examination confirmed metastatic RCC. To date, only 51 cases of metastatic RCC to the ureter have been reported, with only 6 occurring metachronously in the contralateral ureter. Also, we report the presence of focal extramedullary hematopoiesis occurring within this metastatic lesion.