Urology
Volume 64, Issue 2 , Pages 399-404 , August 2004

Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture

  • A Qian

      Affiliations

    • Harbor-UCLA Research and Education Institute, Torrance, California, USA
    • ,
  • R.A Meals

      Affiliations

    • Department of Orthopedics, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • ,
  • J Rajfer

      Affiliations

    • Harbor-UCLA Research and Education Institute, Torrance, California, USA
    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • ,
  • N.F Gonzalez-Cadavid

      Affiliations

    • Harbor-UCLA Research and Education Institute, Torrance, California, USA
    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • Corresponding Author InformationReprint requests: Nestor F. Gonzalez-Cadavid, Ph.D., Department of Urology, Harbor-UCLA Research and Education Institute, Building F-6, 1124 West Carson Street, Torrance, CA 90502, USA

Received 29 December 2003 ,Accepted 7 April 2004.

References 

  1. Gholami SS, Gonzalez-Cadavid NF, Lin C-S, et al.  Peyronie's disease (a review). J Urol. 2002;169:1234–1241
  2. Somers KD, Dawson DM. Fibrin deposition in Peyronie's disease plaque. J Urol. 1997;157:311–315
  3. Davila H, Ferrini M, Rajfer J, et al.  Fibrin induction of a Peyronie's-like plaque in the rat penile tunica albuginea (a new model for Peyronie's disease). Br J Urol. 2003;91:830–838
  4. Ferrini MG, Vernet D, Magee TR, et al.  Antifibrotic role of inducible nitric oxide synthase (iNOS). Nitric Oxide. 2002;6:1–12
  5. Vernet D, Ferrini MG, Valente E, et al.  Effect of nitric oxide on fibroblast differentiation into myofibroblasts in cell cultures from the Peyronie's fibrotic plaque and in its rat model in vivo. Nitric Oxide. 2002;7:262–276
  6. Mulhall JP. Expanding the paradigm for plaque development in Peyronie's disease. Int J Impot Res. 2003;15:S93–S102
  7. Powell DW, Mifflin RC, Valentich JD, et al.  Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol. 1999;277:C1–C9
  8. Valente EG, Ferrini MG, Vernet D, et al.  PDE l-arginine and PDE inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric Oxide. 2003;9:229–244
  9. Fitzgerald AM, Kirkpatrick JJ, Naylor IL. Dupuytren's disease (the way forward?). J Hand Surg [Br]. 1999;24:395–399
  10. Carrieri MP, Serraino D, Palmiotto F, et al.  A case-control study on risk factors for Peyronie's disease. J Clin Epidemiol. 1998;51:511–515
  11. Tomasek JJ, Vaughan MB, Haaksma CJ. Cellular structure and biology of Dupuytren's disease. Hand Clin. 1999;15:21–34
  12. Forster T, Roy D, Ghazal P. Experiments using microarray technology (limitations and standard operating procedures). J Endocrinol. 2003;178:195–204
  13. Magee TR, Qian A, Rajfer J, et al.  Gene expression profiles in the Peyronie's disease plaque. Urology. 2002;59:451–457
  14. Ravanti L, Kahari VM. Matrix metalloproteinases in wound repair. Int J Mol Med. 2000;6:391–407
  15. Huff T, Muller CS, Otto AM, et al.  Beta-thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol. 2001;33:205–220
  16. Philp D, Badamchian M, Scheremeta B, et al.  Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice. Wound Repair Regen. 2003;11:19–24
  17. May RC. The Arp2/3 complex (a central regulator of the actin cytoskeleton). Cell Mol Life Sci. 2001;58:1607–1626
  18. Olofsson B. Rho guanine dissociation inhibitors (pivotal molecules in cellular signaling). Cell Signal. 1999;11:545–554
  19. Tare RS, Oreffo RO, Clarke NM, et al.  Pleiotrophin/osteoblast-stimulating factor 1 (dissecting its diverse functions in bone formation). J Bone Miner Res. 2002;17:2009–2020
  20. Gordeladze JO, Drevon CA, Syversen U, et al.  Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization (impact on differentiation markers, apoptosis, and osteoclastic signaling). J Cell Biochem. 2002;85:825–836
  21. Hashimoto Y, Niikura T, Chiba T, et al.  The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. J Pharmacol Exp Ther. 2003;306:889–902
  22. Nishimura I, Takazaki R, Kuwako K, et al.  Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons. Exp Cell Res. 2003;286:241–251
  23. Teruyama K, Abe M, Nakano T, et al.  Role of transcription factor Ets-1 in the apoptosis of human vascular endothelial cells. J Cell Physiol. 2001;188:243–252
  24. Lee JC, Peter ME. Regulation of apoptosis by ubiquitination. Immunol Rev. 2003;193:39–47
  25. Lenda DM, Kikawada E, Stanley ER, et al.  Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J Immunol. 2003;170:3254–3262
  26. Angel P, Szabowski A. Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. Biochem Pharmacol. 2002;64:949–956
  27. Reed CC, Iozzo RV. The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J. 2002;19:249–255
  28. Kaufmann A, Salentin R, Meyer RG, et al.  Defense against influenza A virus infection (essential role of the chemokine system). Immunobiology. 2001;204:603–613
  29. Forbes JM, Thallas V, Thomas MC, et al.  The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB J. 2003;17:1762–1764
  30. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol. 2003;200:500–503
  31. Mills TM, Chitaley K, Lewis RW, et al.  Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection. Eur J Pharmacol. 2002;439:173–174
  32. Barnham KJ, McKinstry WJ, Multhaup G, et al.  Structure of the Alzheimer's disease amyloid precursor protein copper binding domain (a regulator of neuronal copper homeostasis). J Biol Chem. 2003;278:17401–17407

☆ These studies were funded mainly by a grant from the Eli and Edythe L. Broad Foundation and in part by National Institute of Health grants R01DK-53069 and G12RR-03026.

PII: S0090-4295(04)00433-9

doi: 10.1016/j.urology.2004.04.006

Urology
Volume 64, Issue 2 , Pages 399-404 , August 2004

Article Tools

* Image Usage & Resolution