Urology
Volume 64, Issue 2 , Pages 389-393 , August 2004

Antiproliferative and antiangiogenic activities of genistein in human renal cell carcinoma

  • Hiroto Sasamura

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • ,
  • Atsushi Takahashi

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • Corresponding Author InformationReprint requests: Atsushi Takahashi, M.D., Department of Urology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan
    • ,
  • Jinyang Yuan

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • ,
  • Hiroshi Kitamura

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • ,
  • Naoya Masumori

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • ,
  • Noriomi Miyao

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • ,
  • Naoki Itoh

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
    • ,
  • Taiji Tsukamoto

      Affiliations

    • Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan

Received 29 December 2003 ,Accepted 29 March 2004.

References 

  1. Fotsis T, Pepper M, Adlercreutz H, et al.  Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr. 1995;125:790S–797S
  2. Shao ZM, Alpaugh ML, Fontana JA, et al.  Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis. J Cell Biochem. 1998;69:44–54
  3. Constanitinou A, Kiguchi K, Huberman A. Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res. 1990;50:2618–2624
  4. Hunakova L, Sedlak J, Klobuicka M, et al.  Tyrosine kinase inhibitor-induced differentiation of K-562 cells (alterations of cell cycle and cell surface phenotype). Cancer Lett. 1994;81:81–87
  5. Akiyama T, Ishida J, Nakagawa S, et al.  Genistein, a specific inhibitor of tyrosine-specific protein kinase. J Biol Chem. 1987;262:5592–5595
  6. Okura A, Arakawa H, Oka H, et al.  Effect of genistein on topoisomerase activity on the growth of [VAL 12] Ha-ras-transformed NIH3T3 cells. Biochem Biophys Res Commun. 1988;157:183–189
  7. Adlercreutz H, Bannwart C, Wahala K, et al.  Inhibition of human aromatase by mammalian ligands and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol. 1993;44:147–153
  8. Mäkelä S, Poutanen M, Kostian ML, et al.  Inhibition of 17β-hydroxysteroid oxidoreductase by flavonoids in breast and prostate cancer cells. Proc Soc Exp Biol Med. 1998;217:310–316
  9. Zhou JR, Mukherjee P, Gugger ET, et al.  Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res. 1998;58:5231–5238
  10. Sasamura H, Takahashi A, Miyao N, et al.  Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma. Br J Cancer. 2002;86:768–773
  11. Takahashi A, Sasaki H, Kim SJ, et al.  Markedly Increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 1994;54:4233–4237
  12. Miyao N, Tsukamoto T, Kumamoto Y. Establishment of three human renal cell carcinoma cell lines (SMKT-R-1, SMKT-R-2, and SMKT-R-3) and their characters. Urol Res. 1989;17:317–324
  13. Otani N, Tsukamoto T, Kumamoto Y, et al.  Study on in vitro invasive potential of renal cell carcinoma cell lines and effect of growth factors (EGF and TGF-β1). Jpn J Urol. 1991;82:613–619
  14. Funahashi Y, Wakabayashi T, Senba T, et al.  Establishment of a quantitative mouse dorsal sac model and its application to evaluate a new angiogenesis inhibitor. Oncol Res. 1999;11:319–329
  15. Song CH, Levitt SH. Quantitative study of vascularity in Walker carcinoma 256. Cancer Res. 1971;31:587–589
  16. Peretz D, Kimel N, Fujii DK, et al.  Overexpression of basic fibroblast growth factor complementary DNA in Ha-ras-transformed cells correlates with a decreased incidence of tumor necrosis. Cancer Res. 1993;53:158–164
  17. Balbaa M, Honke K, Makita A. Regulation of glycolipid sulfotransferase by tyrosine kinases in human renal cancer cells. Biochem Biophys Act. 1996;1299:141–145
  18. Davis JN, Singh B, Buoyant M, et al.  Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer. 1998;32:123–131
  19. Park BS, Baek SJ, Song KH, et al.  Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor, lactacystin. Nutr Cancer. 2002;42:248–255
  20. Gong L, Li Y, Nedeljkovic-Kurepa A, et al.  Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cell. Oncogene. 2003;22:4702–4709
  21. Folkman J. Tumor angiogenesis (therapeutic implications). N Engl J Med. 1971;285:1182–1186
  22. Ausprunk DH, Knighton DR, Folkman J. Vascularization of normal and neoplastic tissue grafted to the chick chorioallantois. Am J Pathol. 1975;79:597–618
  23. Gimbrone MA, Cotran RS, Leapman SB, et al.  Tumor growth and neovascularization (a experimental model using rabbit cornea). J Natl Cancer Inst. 1974;52:413–427
  24. Folkman J, Merler E, Abernathy C, et al.  Isolation of a tumor factor responsible for angiogenesis. J Exp Med. 1971;133:275–288
  25. Sakamoto N, Tanaka NG, Tohgo A, et al.  Heparin plus cortisone acetate inhibit tumor growth by blocking endothelial cell proliferation. Cancer J. 1986;1:55–58
  26. Shao ZM, Wu J, Shen ZZ, et al.  Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res. 1998;58:4851–4857
  27. Campbell SC. Advances in angiogenesis research (relevance to urological oncology). J Urol. 1997;158:1663–1667
  28. Mukhopadhyay D, Tsiokas L, Zhou XM, et al.  Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995;375:577–581

☆ This work was supported in part by a Grant-in-Aid from the Japanese Ministry of Education, Science, Sports and Culture, and the Stiftelsen Japanese-Swedish Cooperative Research Foundation.

PII: S0090-4295(04)00417-0

doi: 10.1016/j.urology.2004.03.045

Urology
Volume 64, Issue 2 , Pages 389-393 , August 2004

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