Urology
Volume 61, Issue 6 , Pages 1079-1085 , June 2003

Nitric oxide and the lower urinary tract: current concepts, future prospects

  • Mamas A Mamas

      Affiliations

    • Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
  • ,
  • John M Reynard

      Affiliations

    • National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, United Kingdom
    • Corresponding Author InformationReprint requests: John M. Reynard, M.D., National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, HP21 8AL, United Kingdom
  • ,
  • Alison F Brading

      Affiliations

    • Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Received 7 November 2001 ,Accepted 31 January 2003.

References 

  1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373–376
  2. Moncada S, Palmer RM, Higgis EA. Nitric oxide (physiology, pathophysiology and pharmacology). Pharmacol Rev. 1991;43:109–142
  3. Gillespie JS, Liu XR, Martin W. The effects of l-arginine and NG-monomethyl l-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation. Br J Pharmacol. 1989;98:1080–1082
  4. McNeill DL, Traugh NE, Vaidya AM, et al.  Origin and distribution of NADPH-diaphorase positive neurons and fibers innervating the urinary bladder of the rat. Neurosci Lett. 1992;147:33–36
  5. Vizzard MA, Erdman SL, Forstermann U, et al.  Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat. Brain Res. 1994;646:279–291
  6. Persson K, Alm P, Uvelius B, et al.  Nitrergic and cholinergic innervation of the lower urinary tract after pelvic ganglionectomy. Am J Physiol. 1998;274:R389–R397
  7. Keast JR, Kawatani M. Extensive distribution of NADPH diaphorase activity in the nerve supply of the cat lower urinary tract. J Auton Nerv Syst. 1994;50:161–169
  8. Persson K, Alm P, Johansson K, et al.  Co-existence of nitrergic, peptidergic and acetylcholine esterase-positive nerves in the pig lower urinary tract. J Auton Nerv Syst. 1995;52:225–236
  9. Ho KM, Ny L, McMurray G, et al.  Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter. J Urol. 1999;161:1968–1972
  10. Garcia-Pascual A, Costa G, Labadia A, et al.  Characterization of nitric oxide synthase activity in sheep urinary tract (functional implications). Br J Pharmacol. 1996;118:905–914
  11. Ehren I, Iversen H, Jansson O, et al.  Localization of nitric oxide synthase activity in the human lower urinary tract and its correlation with neuroeffector responses. Urology. 1994;44:683–687
  12. Persson K, Poljakovic M, Johansson K, et al.  Morphological and biochemical investigation of nitric oxide synthase and related enzymes in the rat and pig urothelium. J Histochem Cytochem. 1999;47:739–750
  13. Andersson KE, Garcia-Pascual A, Persson K, et al.  Electrically-induced, nerve-mediated relaxation of rabbit urethra involves nitric oxide. J Urol. 1992;147:253–259
  14. Takeda M, Lepor H. Nitric oxide synthase in dog urethra (a histochemical and pharmacological analysis). Br J Pharmacol. 1995;116:2517–2523
  15. Parlani M, Conte B, Manzini S. Nonadrenergic, noncholinergic inhibitory control of the rat external urethral sphincter (involvement of nitric oxide). J Pharmacol Exp Ther. 1993;265:713–719
  16. Bridgewater M, MacNeil HF, Brading AF. Regulation of tone in pig urethral smooth muscle. J Urol. 1993;150:223–228
  17. Persson K, Igawa Y, Mattiasson A, et al.  Effects of inhibition of the l-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro. Br J Pharmacol. 1992;107:178–184
  18. Fraser MO, Jung SK, Ozawa H. Intraurethral nitric oxide donor relaxes the urethral smooth muscle. (abstract) J Urol. 1998;159:23
  19. Pinna C, Eberini I, Puglisi L, et al.  Presence of constitutive endothelial nitric oxide synthase immunoreactivity in urothelial cells of hamster proximal urethra. Eur J Pharmacol. 1999;367:85–89
  20. Smet PJ, Jonavicius J, Marshall VR, et al.  Distribution of nitric oxide synthase immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience. 1996;71:337–348
  21. Persson K, Andersson KE. Non-adrenergic, non-cholinergic relaxation and levels of cyclic nucleotides in rabbit lower urinary tract. Eur J Pharmacol. 1994;268:159–167
  22. Zygmunt PM, Zygmunt PK, Hogestatt ED, et al.  Effects of omega-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor. Br J Pharmacol. 1993;110:1285–1290
  23. James MJ, Birmingham AT, Hill SJ. Partial mediation by nitric oxide of the relaxation of human isolated detrusor strips in response to electrical field stimulation. Br J Clin Pharmacol. 1993;35:366–372
  24. Triguero D, Costa G, Labadia A, et al.  Spontaneous photorelaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission. J Physiol. 2000;522:443–456
  25. Hawthorn MH, Chapple CR, Cock M, et al.  Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol. 2000;129:416–419
  26. Bennett BC, Kruse MN, Roppolo JR, et al.  Neural control of urethral outlet activity in vivo (role of nitric oxide). J Urol. 1995;153:2004–2009
  27. Burnett AL, Calvin DC, Chamness SL, et al.  Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nat Med. 1997;3:571–574
  28. Sutherland RS, Kogan BA, Piechota HJ, et al.  Vesicourethral function in mice with genetic disruption of neuronal nitric oxide synthase. J Urol. 1997;157:1109–1116
  29. Mevorach RA, Bogaert GA, Kogan BA: Role of nitric oxide in fetal lower urinary tract function. J Urol 152 (2 Pt 1): 510–514, 1994
  30. Theobald RJ. The effect of NG-monomethyl-l-arginine on bladder function. Eur J Pharmacol. 1996;311:73–78
  31. Frankel HL, Coll JR, Charlifue SW, et al.  Long-term survival in spinal cord injury (a fifty year investigation). Spinal Cord. 1998;36:266–274
  32. Carrion HM, Brown BT, Politano VA. External sphincterotomy at the 12 o’clock position. J Urol. 1979;121:462–463
  33. Catz A, Luttwak ZP, Agranov E, et al.  The role of external sphincterotomy for patients with spinal cord lesions. Spinal Cord. 1997;35:48–52
  34. Kim YH, Kattan MW, Boone TB. Bladder leak point pressure (the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia). J Urol. 1998;159:493–496
  35. Juma S, Mostafavi M, Joseph A. Sphincterotomy (long-term complications and warning signs). Neurourol Urodyn. 1995;14:33–41
  36. Yang CC, Mayo ME. External urethral sphincterotomy (long-term follow-up). Neurourol Urodyn. 1995;14:25–31
  37. Wein AJ. The role of external sphincterotomy for patients with a spinal cord lesion. J Urol. 1998;160:961
  38. Chancellor MB, Bennett C, Simoneau AR, et al.  Sphincteric stent versus external sphincterotomy in spinal cord injured men (prospective randomized multicenter study). J Urol. 1999;161:1893–1898
  39. Dykstra DD, Sidi AA. Treatment of detrusor-sphincter dyssynergia with botulinum A toxin (a double-blind study). Arch Phys Med Rehabil. 1990;71:24–26
  40. Chancellor MB, Erhard MJ, Rivas DA. Clinical effect of alpha-1 antagonism by terazosin on external and internal urinary sphincter function. J Am Para Soc. 1993;16:207–214
  41. Mamas MA, Reynard JM, Brading AF. Augmentation of nitric oxide to treat detrusor-external sphincter dyssynergia in spinal cord injury. Lancet. 2001;357:1964–1967
  42. Gosling JA, Dixon JS. Structure of the bladder and urethra. In:  Whitfield HN,  Hendry WF,  Kirby RS, et al. editor. Textbook of Genitourinary Surgery. Oxford: Blackwell Science; 1998;p. 447–457
  43. Greenland JE, Dass N, Brading AF. Intrinsic urethral closure mechanisms in the female pig. Scand J Urol Nephrol. 1996;30(suppl 179):75–80
  44. Torrens MJ. Urethral sphincteric responses to stimulation of sacral nerves in the human female. Urol Int. 1978;33:22–26
  45. Thind P. The significance of smooth and striated muscles in sphincter function of the urethra in healthy women. Neurourol Urodyn. 1995;14:585–618

PII: S0090-4295(03)00131-6

doi: 10.1016/S0090-4295(03)00131-6

Urology
Volume 61, Issue 6 , Pages 1079-1085 , June 2003