Objective evidence of a high prevalence of renal damage in women with type 2 diabetes by technetium-99m DMSA renal cortex scan findings
Received 18 June 2002; accepted 30 August 2002.
Abstract
Objectives
To compare control women with men and women with type 2 diabetes mellitus (DM) for the prevalence and type of renal damage due to urinary tract infections (UTIs) using technetium-99m dimercapto-succinic acid (99mTc DMSA) renal scanning. Women with DM have UTIs more often than do women without DM. It is unknown, however, what the prevalence and type of renal damage due to UTI are in these women.
Methods
Three groups of patients: 28 control women without type 2 DM and a history of UTIs, 25 male patients with type 2 DM but without a history of UTIs, and 103 female patients with type 2 DM underwent 99mTc DMSA renal scan. The 103 women with type 2 DM were separated into three groups: 36 women without a history of UTIs, 34 patients with a history of cystitis only, and 33 with a history of pyelonephritis.
Results
All the control women and male patients with type 2 DM without a history of UTIs had normal 99mTc DMSA renal scan findings. However, 39.8% of women with type 2 DM had abnormal 99mTc DMSA renal scan findings. Women with type 2 DM without a history of UTI had a significantly lower prevalence of abnormal renal scan findings than did those with a history of cystitis only or pyelonephritis. In addition, the prevalence of abnormal renal scan findings was significantly higher in women with type 2 DM with pyelonephritis than in those with a history of cystitis only. Renal scars on 99mTc DMSA renal scans were found in women with type 2 DM and a history of pyelonephritis.
Conclusions
Compared with control women and men with type 2 DM, women with type 2 DM, especially if they had a history of UTIs, had a significantly higher prevalence of abnormal 99mTc DMSA renal scan findings.
aDepartment of Urology, China Medical College Hospital, Taichung, Taiwan
cDepartment of Family Medicine, China Medical College Hospital, Taichung, Taiwan
dDepartment of Medical Research, China Medical College Hospital, Taichung, Taiwan
eDepartment of Nuclear Medicine, China Medical College Hospital, Taichung, Taiwan
bDepartment of Nuclear Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
Reprint requests: Hsi-Chin Wu, M.D., Department of Urology, China Medical College Hospital, No. 2, Yuh-Der Road, Taichung 404, Taiwan
ABSTRACT