Urology
Volume 59, Issue 6 , Pages 826-830 , June 2002

Effect of ketorolac on renal function after donor nephrectomy

  • Stephen J Freedland

      Affiliations

    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • ,
  • Malou Blanco-Yarosh

      Affiliations

    • Department of Nursing, University of California, Los Angeles, Center for Health Sciences, Los Angeles, California, USA
    • University of California, Los Angeles, Graduate School of Nursing, Los Angeles, California, USA
    • ,
  • Jennifer C Sun

      Affiliations

    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • ,
  • Susan J Hale

      Affiliations

    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • ,
  • David A Elashoff

      Affiliations

    • Department of Biostatistics, University of California, Los Angeles, School of Public Health, Los Angeles, California, USA
    • ,
  • Jacob Rajfer

      Affiliations

    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    • ,
  • H.Albin Gritsch

      Affiliations

    • Corresponding Author InformationReprint requests: H. Albin Gritsch, M.D., Department of Urology, University of California, Los Angeles, School of Medicine, Box 951738, Los Angeles, CA 90095-1738, USA
    • Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA

Received 8 October 2001 ,Revised 21 December 2001 ,Accepted 21 December 2001.

References 

  1. Gillis JC, Brogden RN. Ketorolac (a reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management). Drugs. 1997;53:139–188
  2. Sutters KA, Shaw BA, Gerardi JA, et al.  Comparison of morphine patient-controlled analgesia with and without ketorolac for postoperative analgesia in pediatric orthopedic surgery. Am J Orthop. 1999;28:351–358
  3. Sevarino FB, Sinatra RS, Paige D, et al.  Intravenous ketorolac as an adjunct to patient-controlled analgesia (PCA) for management of postgynecologic surgical pain. J Clin Anesth. 1994;6:23–27
  4. Picard P, Bazin JE, Conio N, et al.  Ketorolac potentiates morphine in postoperative patient-controlled analgesia. Pain. 1997;73:401–406
  5. Garcia Rodriguez LA, Cattaruzzi C, Troncon MG, et al.  Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs. Arch Intern Med. 1998;158:33–39
  6. Strom BL, Berlin JA, Kinman JL, et al.  Parenteral ketorolac and risk of gastrointestinal and operative site bleeding (a postmarketing surveillance study). JAMA. 1996;275:376–382
  7. Feldman HI, Kinman JL, Berlin JA, et al.  Parenteral ketorolac (the risk for acute renal failure). Ann Intern Med. 1997;126:193–199
  8. Lee A, Cooper MG, Craig JC, et al.  The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on postoperative renal function (a meta-analysis). Anaesth Intens Care. 1999;27:574–580
  9. Licker A, Hohn L, Schweizer A. Ketorolac does not increase the risk of renal dysfunction after lung surgery. Br J Anaesth. 1998;81:484–485
  10. Litwin MS, Smith RB, Thind A, et al.  Cost-efficient radical prostatectomy with a clinical care path. J Urol. 1996;155:989–993
  11. Freedland SJ, Blanco-Yarosh M, Sun JS, et al.  Ketorolac-based analgesia improves outcomes for living kidney donors. Transplantation. 2002;73:741–745
  12. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  13. Pugliese F, Ciabattoni G. The role of prostaglandins in the control of renal function (renal effects of nonsteroidal anti-inflammatory drugs). Clin Exp Rheumatol. 1984;2:345–352
  14. Levenson DJ, Simmons CE, Brenner BM. Arachidonic acid metabolism, prostaglandins and the kidney. Am J Med. 1982;72:354–374
  15. DiBona GF. Prostaglandins and nonsteroidal anti-inflammatory drugs (effects on renal hemodynamics). Am J Med. 1986;80:12–21
  16. Cinotti GA. Interactions of renin, kinins and prostaglandins. J Hypertens Suppl. 1983;1:43–51
  17. Dunn MJ. Nonsteroidal antiinflammatory drugs and renal function. Annu Rev Med. 1984;35:411–428
  18. Delmas PD. Non-steroidal anti-inflammatory drugs and renal function. Br J Rheumatol. 1995;34(suppl 1):25–28
  19. Whelton A, Hamilton CW. Nonsteroidal anti-inflammatory drugs (effects on kidney function). J Clin Pharmacol. 1991;31:588–598
  20. Lieh-Lai MW, Kauffman RE, Uy HG, et al.  A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children. Crit Care Med. 1999;27:2786–2791
  21. Lee A, Cooper MG, Craig JC, et al.  Effects of nonsteroidal anti-inflammatory drugs on post-operative renal function in adults (Cochrane review). Cochrane Database Syst Rev. 2000;4:CD002765
  22. Haragsim L, Dalal R, Bagga H, et al.  Ketorolac-induced acute renal failure and hyperkalemia (report of three cases). Am J Kidney Dis. 1994;24:578–580
  23. Pearce CJ, Gonzalez FM, Wallin JD. Renal failure and hyperkalemia associated with ketorolac tromethamine. Arch Intern Med. 1993;153:1000–1002
  24. Simckes AM, Chen SS, Osorio AV, et al.  Ketorolac-induced irreversible renal failure in sickle cell disease (a case report). Pediatr Nephrol. 1999;13:63–67

☆ This study was supported by the Departments of Urology and Nursing, University of California, Los Angeles, Los Angeles, California.

PII: S0090-4295(02)01514-5

Urology
Volume 59, Issue 6 , Pages 826-830 , June 2002

Article Tools

* Image Usage & Resolution