Urology
Volume 57, Issue 4, Supplement 1 , Pages 77-80 , April 2001

Tyrosine kinase inhibitors and signal transduction modulators: Rationale and current status as chemopreventive agents for prostate cancer

  • Raymond C Bergan

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical School and the Robert H. Lurie Cancer Center of Northwestern University, Chicago, Illinois, USA (RCB)
    • Corresponding Author InformationReprint requests: Raymond C. Bergan, MD, Olson 8524, 710 North Fairbanks, Chicago, IL 60611-3008
    • ,
  • Doyle H Waggle

      Affiliations

    • Protein Technologies International, St. Louis, Missouri, USA (DHW)
    • ,
  • Stephen K Carter

      Affiliations

    • Sugen, Inc., San Francisco, California, USA (SKC)
    • ,
  • Ivan Horak

      Affiliations

    • Pharmacia, Peapack, New Jersey, USA (IH)
    • ,
  • William Slichenmyer

      Affiliations

    • Parke-Davis, Ann Arbor, Michigan, USA (WS)
    • ,
  • Michael Meyers

      Affiliations

    • Aventis Inc., Parsippany, New Jersey, USA (MM)

References 

  1. Ware JL. Growth factor network disruption in prostate cancer progression. Cancer Metast Rev. 1998;17:443–447
  2. Porter AC, Vaillancourt RR. Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene. 1998;17:1343–1352
  3. Ron D, Kazanietz MG. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J. 1999;13:1658–1676
  4. Schlesinger TK, Fanger GR, Yujiri T, et al.  The TAO of MEKK. Front Biosci. 1998;3:D1181–D1186
  5. Adlercreutz H. Western diet and Western diseases (some hormonal and biochemical mechanisms and associations). Scand J Clin Lab Invest. 1990;50(suppl 201):3–23
  6. Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet. 1993;342:1209–1210
  7. Bergan R, Kyle E, Nguyen P, et al.  Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin. Clin Exp Metast. 1996;14:389–398
  8. Kyle E, Neckers L, Takimoto C, et al.  Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol. 1997;51:193–200
  9. Liu YQ, Kyle E, Bergan RC. Differentially expressed transcripts during prostate cancer metastasis (abstract). Proc Am Assoc Cancer Res. 1999;40:72A
  10. Ching KZ, Ramsey E, Pettigrew N, et al.  Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell lines. Mol Cell Biochem. 1993;126:151–158
  11. Glynne-Jones E, Goddard L, Harper ME. Comparative analysis of mRNA and protein expression for epidermal growth factor receptor and ligands relative to the proliferative index in human prostate tissue. Hum Pathol. 1996;27:688–694
  12. Olapade-Olaopa EO, Moscatello DK, MacKay EH, et al.  Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer. Br J Cancer. 2000;82:186–194

PII: S0090-4295(00)00946-8

Urology
Volume 57, Issue 4, Supplement 1 , Pages 77-80 , April 2001

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