Urology
Volume 56, Issue 2 , Pages 283-288 , August 2000

Adenocarcinoma of the prostate invading the seminal vesicle: prognostic stratification based on pathologic parameters

  • Jonathan I Epstein

      Affiliations

    • Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    • James Buchanan Brady Urological Institute, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    • Corresponding Author InformationReprint requests: Jonathan I. Epstein, M.D., Department of Pathology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287
    • ,
  • Alan W Partin

      Affiliations

    • Department of Urology, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    • James Buchanan Brady Urological Institute, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    • ,
  • Steven R Potter

      Affiliations

    • James Buchanan Brady Urological Institute, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    • ,
  • Patrick C Walsh

      Affiliations

    • Department of Urology, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    • James Buchanan Brady Urological Institute, Johns Hopkins Medical Institution, Baltimore, Maryland, USA

Received 25 October 1999 ,Revised 3 April 2000 ,Accepted 3 April 2000.

References 

  1. McNeal JE, Villers AA, Redwine EA, et al.  Histologic differentiation, cancer volume, and pelvic node metastasis in adenocarcinoma of the prostate. Cancer. 1990;66:1225–1233
  2. Partin AW, Epstein JI, Cho KR, et al.  Morphometric measurement of tumor volume and percent of gland involvement as predictors of pathologic stage in stage B prostate cancer. J Urol. 1989;141:341–345
  3. McNeal JE, Yemoto CEM. Spread of adenocarcinoma within prostatic ducts and acini (morphologic and clinical correlations). Am J Surg Pathol. 1996;20:802–814
  4. D’Amico A, Whittington R, Malkowicz SB, et al.  A multivariate analysis of clinical and pathological factors that predict for prostate specific antigen failure after radical prostatectomy for prostate cancer. J Urol. 1995;154:131–138
  5. Van den Ouden D, Hop WCJ, Kranse R, et al.  Tumour control according to pathological variables in patients treated by radical prostatectomy for clinically localized carcinoma of the prostate. Br J Urol. 1997;79:203–211
  6. Debras B, Guillonneau B, Bougaran J, et al.  Prognostic significance of seminal vesicle invasion on the radical prostatectomy specimen. Eur Urol. 1998;33:271–277
  7. Catalona WJ, Smith DS. 5-year tumor recurrence rates after anatomical radical retropubic prostatectomy for prostate cancer. J Urol. 1994;152:1837–1842
  8. Epstein JI, Partin AW, Sauvageot J, et al.  Prediction of progression following radical prostatectomy (a multivariate analysis of 721 men with long-term follow-up). Am J Surg Pathol. 1996;20:286–292
  9. Tefilli MV, Gheiler EL, Riguert R, et al.  Prognostic indicators in patients with seminal vesicle involvement following radical prostatectomy for clinically localized prostate cancer. J Urol. 1988;160:802–806
  10. Ohori M, Wheeler TM, Kattan MW, et al.  Prognostic significance of positive surgical margins in radical prostatectomy specimens. J Urol. 1995;154:1818–1824
  11. Trapasso JG, deKernion JB, Smith RB, et al.  The incidence and significance of detectable levels of serum prostate specific antigen after radical prostatectomy. J Urol. 1994;152:1821–1825
  12. Soh S, Arakawa A, Suyama K, et al.  The prognosis of patients with seminal vesicle involvement depends upon the level of extraprostatic extension. J Urol. 1998;159:296A
  13. Villers AA, McNeal JE, Redwine EA, et al.  Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma. J Urol. 1990;143:1183–1187
  14. Ohori M, Scardino PT, Lapin SL, et al.  The mechanisms and prognostic significance of seminal vesicle involvement by prostate cancer. Am J Surg Pathol. 1993;17:1252–1261
  15. Epstein JI, Carmichael M, Walsh PC. Adenocarcinoma of the prostate invading the seminal vesicle (definition and relation of tumor volume, grade and margins of resection to prognosis). J Urol. 1993;149:1040–1045
  16. Salomao DR, Graham SD, Bostwick DG. Microvascular invasion in prostate cancer correlates with pathologic stage. Arch Pathol Lab Med. 1995;119:1050–1054
  17. Bahnson RR, Dresner SM, Gooding W, et al.  Incidence and prognostic significance of lymphatic and vascular invasion in radical prostatectomy specimens. Prostate. 1989;15:149–155
  18. McNeal JE, Yemoto CEM. Significance of demonstrable vascular space invasion for progression of prostatic adenocarcinoma. Am J Surg Pathol. 1996;20:1351–1360
  19. Potter SR, Mangold LA, Shue MS, et al.  Molecular staging of men with seminal vesicle invasion and negative lymph nodes at radical prostatectomy. J Urol. 1999;161(suppl):235

☆ This study was supported by NIH SPORE CA58236.

PII: S0090-4295(00)00640-3

Urology
Volume 56, Issue 2 , Pages 283-288 , August 2000

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