Long-term survival probability in men with clinically localized prostate cancer treated either conservatively or with definitive treatment (radiotherapy or radical prostatectomy)
Received 3 January 2006; accepted 11 August 2006.
Abstract
Objectives
To report the long-term survival probability in more than 3000 men with localized prostate cancer treated either conservatively or by definitive treatment (radiotherapy or radical prostatectomy).
Methods
We studied 3159 men with biopsy-confirmed, clinically localized prostate cancer diagnosed from 1980 to 1997. We restricted our analysis to men 75 years of age or younger. The extent of comorbid disease was measured using the Charlson score. The Cox proportional hazards regression model was used to compare long-term survival in patients who were treated conservatively versus survival in patients treated with either radiotherapy or radical prostatectomy.
Results
After adjusting for age, race, tumor grade, comorbid disease, income status, and year of diagnosis, the overall survival rate at 15 years was 35% for conservative management, 50% for radiotherapy, and 65% for radical prostatectomy. The corresponding prostate cancer-specific survival rates were 79%, 87%, and 92%. Patients undergoing radiotherapy or radical prostatectomy had lower overall mortality than patients undergoing conservative management (adjusted relative risk 0.67 for radiotherapy and 0.41 for prostatectomy; P <0.001). The increase in the survival duration was 4.6 years with radiotherapy and 8.6 years with radical prostatectomy.
Conclusions
The results of this study have shown that compared with conservative management, both radiotherapy and radical prostatectomy increase survival for men with localized prostate cancer.
aDepartment of Urology, New York-Presbyterian Hospital, Cornell University Weill Medical College, New York, New York
bDepartment of Radiation Oncology, Vattikuti Urology Institute, Josephine Ford Cancer Center, Henry Ford Health System, Detroit, Michigan
Reprint requests: Ashutosh Tewari, M.D., M.Ch., Department of Urology, New York-Presbyterian Hospital–Weill Cornell Medical Center, 525 East 68th Street, Starr 900, New York, NY 10021
ABSTRACT